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Case Report

Nocturnal Enuresis in a Postmenopausal Woman: A Case Report and Review of Literature

Pantaleo Mng’onge Joseph and Peace Patrick Lwekamwa*

Corresponding Author: Peace Patrick Lwekamwa, Department of Internal Medicine, Mwananyamala Regional Referral Hospital, P.O. Box 61665, Dar-es-salaam, Tanzania

Received: March 22, 2025 ;    Revised: April 24, 2025 ;    Accepted: April 27, 2025 ;   Available Online: May 06, 2025

Citation: Joseph PM & Lwekamwa PP. (2025) Nocturnal Enuresis in a Postmenopausal Woman: A Case Report and Review of Literature. J Women Health Gynecol Res, 2(1): 1-4.

Copyrights: ©2025 Joseph PM & Lwekamwa PP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Background: Nocturnal enuresis (NE) is a rare condition in adults, particularly in postmenopausal women. It is often linked to multiple factors including hormonal changes, comorbidities, and sleep disorders. Hormonal deficiency, particularly estrogen, has been implicated in the pathophysiology of lower urinary tract symptoms (LUTS) in postmenopausal women, contributing to bladder dysfunction and urethral instability. This case report presents a postmenopausal woman with NE, highlighting the importance of a thorough diagnostic approach, management strategies, and the underlying pathophysiological mechanisms.

Case Presentation: A 53-year-old multiparous woman, three years post menopause, presented with a two-week history of NE, experiencing 3-4 episodes of bedwetting per week. Urinalysis revealed no abnormalities, and hormonal profiling confirmed hypoestrogenism (FSH: 72 IU/L, estradiol: <20 pg/mL). MRI of the brain and polysomnography were recommended to exclude neurological issues and obstructive sleep apnea (OSA). The management plan included oral desmopressin (0.2 mg twice daily) and behavioral modifications.

Conclusion: Postmenopausal NE is associated with hormonal, neurological, and sleep-related factors. Local estrogen therapy and targeted investigations, such as sleep studies, are crucial for effective management. This case highlights the importance of a multidisciplinary approach integrating hormonal therapy, pharmacotherapy, and lifestyle adjustments. Further research is needed to establish evidence-based guidelines for managing NE in postmenopausal women.

Keywords: Nocturnal enuresis, Post menopause, Estrogen decline, Bladder dysfunction, Hormonal therapy, Case report

 

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